About Corticotropin-releasing factor receptor 2
Corticotropin-releasing factor receptor 2 (CRHR2) is a protein
from Homo sapiens identified by UniProt accession
Q13324, 411 residues long.
MolForge cross-references it against 0 known binders and
176 disease associations.
Target properties
| Protein name | Corticotropin-releasing factor receptor 2 |
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| UniProt accession | Q13324 |
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| Gene | CRHR2 |
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| Organism | Homo sapiens |
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| Length | 411 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (176)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.40
- hemoglobin A1 measurement · score 0.29
- Abnormality of the digestive system · score 0.27
- gastrointestinal disease · score 0.27
- glioblastoma multiforme · score 0.17
- HbA1c measurement · score 0.17
- neoplasm · score 0.08
- major depressive disorder · score 0.08
- irritable bowel syndrome · score 0.07
- obsessive-compulsive disorder · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13324-F1 | alphafold | PREDICTED | 78.37 | — |
Amino-acid sequence (411 residues)
MDAALLHSLL EANCSLALAE ELLLDGWGPP LDPEGPYSYC NTTLDQIGTC WPRSAAGALV ERPCPEYFNG VKYNTTRNAY RECLENGTWA SKINYSQCEP ILDDKQRKYD LHYRIALVVN YLGHCVSVAA LVAAFLLFLA LRSIRCLRNV IHWNLITTFI LRNVMWFLLQ LVDHEVHESN EVWCRCITTI FNYFVVTNFF WMFVEGCYLH TAIVMTYSTE RLRKCLFLFI GWCIPFPIIV AWAIGKLYYE NEQCWFGKEP GDLVDYIYQG PIILVLLINF VFLFNIVRIL MTKLRASTTS ETIQYRKAVK ATLVLLPLLG ITYMLFFVNP GEDDLSQIMF IYFNSFLQSF QGFFVSVFYC FFNGEVRSAV RKRWHRWQDH HSLRVPMARA MSIPTSPTRI SFHSIKQTAA V
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