About Centromere protein R
Centromere protein R (ITGB3BP) is a protein
from Homo sapiens identified by UniProt accession
Q13352, 177 residues long.
MolForge cross-references it against 0 known binders and
80 disease associations.
Target properties
| Protein name | Centromere protein R |
|---|
| UniProt accession | Q13352 |
|---|
| Gene | ITGB3BP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 177 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (80)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.25
- mean reticulocyte volume · score 0.23
- eye color · score 0.22
- mean corpuscular hemoglobin · score 0.22
- protein measurement · score 0.14
- type 2 diabetes mellitus · score 0.13
- serum gamma-glutamyl transferase measurement · score 0.13
- type 1 diabetes mellitus · score 0.13
- alcohol drinking · score 0.09
- Blackfan-Diamond anemia · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13352-F1 | alphafold | PREDICTED | 72.44 | — |
Amino-acid sequence (177 residues)
MPVKRSLKLD GLLEENSFDP SKITRKKSVI TYSPTTGTCQ MSLFASPTSS EEQKHRNGLS NEKRKKLNHP SLTESKESTT KDNDEFMMLL SKVEKLSEEI MEIMQNLSSI QALEGSRELE NLIGISCASH FLKREMQKTK ELMTKVNKQK LFEKSTGLPH KASRHLDSYE FLKAILN
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