About Origin recognition complex subunit 2
Origin recognition complex subunit 2 (ORC2) is a protein
from Homo sapiens identified by UniProt accession
Q13416, 577 residues long.
MolForge cross-references it against 0 known binders and
19 disease associations.
Target properties
| Protein name | Origin recognition complex subunit 2 |
|---|
| UniProt accession | Q13416 |
|---|
| Gene | ORC2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 577 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (19)
Diseases linked to this target (Open Targets).
- endometrial cancer · score 0.27
- lung adenocarcinoma · score 0.23
- breast adenocarcinoma · score 0.23
- small cell lung carcinoma · score 0.19
- neurodegenerative disease · score 0.18
- gastric adenocarcinoma · score 0.10
- total blood protein measurement · score 0.07
- mean platelet volume · score 0.06
- body height · score 0.04
- monocyte count · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13416-F1 | alphafold | PREDICTED | 64.40 | — |
Amino-acid sequence (577 residues)
MSKPELKEDK MLEVHFVGDD DVLNHILDRE GGAKLKKERA QLLVNPKKII KKPEYDLEED DQEVLKDQNY VEIMGRDVQE SLKNGSATGG GNKVYSFQNR KHSEKMAKLA SELAKTPQKS VSFSLKNDPE ITINVPQSSK GHSASDKVQP KNNDKSEFLS TAPRSLRKRL IVPRSHSDSE SEYSASNSED DEGVAQEHEE DTNAVIFSQK IQAQNRVVSA PVGKETPSKR MKRDKTSDLV EEYFEAHSSS KVLTSDRTLQ KLKRAKLDQQ TLRNLLSKVS PSFSAELKQL NQQYEKLFHK WMLQLHLGFN IVLYGLGSKR DLLERFRTTM LQDSIHVVIN GFFPGISVKS VLNSITEEVL DHMGTFRSIL DQLDWIVNKF KEDSSLELFL LIHNLDSQML RGEKSQQIIG QLSSLHNIYL IASIDHLNAP LMWDHAKQSL FNWLWYETTT YSPYTEETSY ENSLLVKQSG SLPLSSLTHV LRSLTPNARG IFRLLIKYQL DNQDNPSYIG LSFQDFYQQC REAFLVNSDL TLRAQLTEFR DHKLIRTKKG TDGVEYLLIP VDNGTLTDFL EKEEEEA
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