About Transmembrane emp24 domain-containing protein 1
Transmembrane emp24 domain-containing protein 1 (TMED1) is a protein
from Homo sapiens identified by UniProt accession
Q13445, 227 residues long.
MolForge cross-references it against 0 known binders and
17 disease associations.
Target properties
| Protein name | Transmembrane emp24 domain-containing protein 1 |
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| UniProt accession | Q13445 |
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| Gene | TMED1 |
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| Organism | Homo sapiens |
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| Length | 227 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (17)
Diseases linked to this target (Open Targets).
- age at diagnosis · score 0.08
- hyperlipidemia · score 0.08
- Ischemic stroke · score 0.06
- BMI-adjusted waist-hip ratio · score 0.05
- cancer · score 0.03
- mean corpuscular volume · score 0.03
- eosinophil count · score 0.02
- diastolic blood pressure · score 0.02
- psoriasis · score 0.02
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13445-F1 | alphafold | PREDICTED | 83.05 | — |
Amino-acid sequence (227 residues)
MMAAGAALAL ALWLLMPPVE VGGAGPPPIQ DGEFTFLLPA GRKQCFYQSA PANASLETEY QVIGGAGLDV DFTLESPQGV LLVSESRKAD GVHTVEPTEA GDYKLCFDNS FSTISEKLVF FELIFDSLQD DEEVEGWAEA VEPEEMLDVK MEDIKESIET MRTRLERSIQ MLTLLRAFEA RDRNLQEGNL ERVNFWSAVN VAVLLLVAVL QVCTLKRFFQ DKRPVPT
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