Limbic system-associated membrane protein (LSAMP)

About Limbic system-associated membrane protein

Limbic system-associated membrane protein (LSAMP) is a protein from Homo sapiens identified by UniProt accession Q13449, 338 residues long. MolForge cross-references it against 0 known binders and 98 disease associations.

Target properties

Protein name	Limbic system-associated membrane protein
UniProt accession	Q13449
Gene	LSAMP
Organism	Homo sapiens
Length	338 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (98)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.46
neuroticism measurement · score 0.43
body mass index · score 0.42
mathematical ability · score 0.41
protein measurement · score 0.32
Abnormal conjugate eye movement · score 0.32
Nystagmus · score 0.32
body weight · score 0.31
unipolar depression · score 0.30
mood disorder · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13449-F1	alphafold	PREDICTED	83.75	—

Amino-acid sequence (338 residues)

MVRRVQPDRK QLPLVLLRLL CLLPTGLPVR SVDFNRGTDN ITVRQGDTAI LRCVVEDKNS KVAWLNRSGI IFAGHDKWSL DPRVELEKRH SLEYSLRIQK VDVYDEGSYT CSVQTQHEPK TSQVYLIVQV PPKISNISSD VTVNEGSNVT LVCMANGRPE PVITWRHLTP TGREFEGEEE YLEILGITRE QSGKYECKAA NEVSSADVKQ VKVTVNYPPT ITESKSNEAT TGRQASLKCE ASAVPAPDFE WYRDDTRINS ANGLEIKSTE GQSSLTVTNV TEEHYGNYTC VAANKLGVTN ASLVLFRPGS VRGINGSISL AVPLWLLAAS LLCLLSKC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards