About Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3 (TUSC3) is a protein
from Homo sapiens identified by UniProt accession
Q13454, 348 residues long.
MolForge cross-references it against 0 known binders and
112 disease associations.
Target properties
| Protein name | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3 |
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| UniProt accession | Q13454 |
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| Gene | TUSC3 |
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| Organism | Homo sapiens |
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| Length | 348 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (112)
Diseases linked to this target (Open Targets).
- autosomal recessive non-syndromic intellectual disability · score 0.64
- Intellectual disability · score 0.50
- genetic disorder · score 0.48
- body mass index · score 0.41
- COVID-19 · score 0.37
- mathematical ability · score 0.34
- response to paracetamol · score 0.31
- schizophrenia symptom severity measurement · score 0.28
- self reported educational attainment · score 0.27
- diffuse plaque measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13454-F1 | alphafold | PREDICTED | 84.77 | — |
Amino-acid sequence (348 residues)
MGARGAPSRR RQAGRRLRYL PTGSFPFLLL LLLLCIQLGG GQKKKENLLA EKVEQLMEWS SRRSIFRMNG DKFRKFIKAP PRNYSMIVMF TALQPQRQCS VCRQANEEYQ ILANSWRYSS AFCNKLFFSM VDYDEGTDVF QQLNMNSAPT FMHFPPKGRP KRADTFDLQR IGFAAEQLAK WIADRTDVHI RVFRPPNYSG TIALALLVSL VGGLLYLRRN NLEFIYNKTG WAMVSLCIVF AMTSGQMWNH IRGPPYAHKN PHNGQVSYIH GSSQAQFVAE SHIILVLNAA ITMGMVLLNE AATSKGDVGK RRIICLVGLG LVVFFFSFLL SIFRSKYHGY PYSDLDFE
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