Sequestosome-1 (SQSTM1)

About Sequestosome-1

Sequestosome-1 (SQSTM1) is a protein from Homo sapiens identified by UniProt accession Q13501, 440 residues long. MolForge cross-references it against 0 known binders and 624 disease associations.

Target properties

Protein name	Sequestosome-1
UniProt accession	Q13501
Gene	SQSTM1
Organism	Homo sapiens
Length	440 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (624)

Diseases linked to this target (Open Targets).

osteitis deformans · score 0.79
neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset · score 0.71
amyotrophic lateral sclerosis · score 0.66
behavioral variant of frontotemporal dementia · score 0.66
frontotemporal dementia with motor neuron disease · score 0.66
Distal myopathy, Nonaka type · score 0.61
frontotemporal dementia and/or amyotrophic lateral sclerosis 1 · score 0.55
cancer · score 0.49
osteosarcoma · score 0.49
neurodegenerative disease · score 0.45

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13501-F1	alphafold	PREDICTED	67.25	—

Amino-acid sequence (440 residues)

MASLTVKAYL LGKEDAAREI RRFSFCCSPE PEAEAEAAAG PGPCERLLSR VAALFPALRP GGFQAHYRDE DGDLVAFSSD EELTMAMSYV KDDIFRIYIK EKKECRRDHR PPCAQEAPRN MVHPNVICDG CNGPVVGTRY KCSVCPDYDL CSVCEGKGLH RGHTKLAFPS PFGHLSEGFS HSRWLRKVKH GHFGWPGWEM GPPGNWSPRP PRAGEARPGP TAESASGPSE DPSVNFLKNV GESVAAALSP LGIEVDIDVE HGGKRSRLTP VSPESSSTEE KSSSQPSSCC SDPSKPGGNV EGATQSLAEQ MRKIALESEG RPEEQMESDN CSGGDDDWTH LSSKEVDPST GELQSLQMPE SEGPSSLDPS QEGPTGLKEA ALYPHLPPEA DPRLIESLSQ MLSMGFSDEG GWLTRLLQTK NYDIGAALDT IQYSKHPPPL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards