Acid ceramidase (ASAH1)

About Acid ceramidase

Acid ceramidase (ASAH1) is a protein from Homo sapiens identified by UniProt accession Q13510, 395 residues long. MolForge cross-references it against 0 known binders and 1,455 disease associations.

Target properties

Protein name	Acid ceramidase
UniProt accession	Q13510
Gene	ASAH1
Organism	Homo sapiens
Length	395 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (1455)

Diseases linked to this target (Open Targets).

Farber lipogranulomatosis · score 0.84
spinal muscular atrophy-progressive myoclonic epilepsy syndrome · score 0.80
Hereditary myoclonus - progressive distal muscular atrophy · score 0.79
ASAH1-related disorders · score 0.48
childhood epilepsy with centrotemporal spikes · score 0.45
Rolandic epilepsy · score 0.45
genetic disorder · score 0.41
hydrops fetalis · score 0.37
Intellectual disability · score 0.37
Non-immune hydrops fetalis · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13510-F1	alphafold	PREDICTED	91.52	—

Amino-acid sequence (395 residues)

MPGRSCVALV LLAAAVSCAV AQHAPPWTED CRKSTYPPSG PTYRGAVPWY TINLDLPPYK RWHELMLDKA PVLKVIVNSL KNMINTFVPS GKIMQVVDEK LPGLLGNFPG PFEEEMKGIA AVTDIPLGEI ISFNIFYELF TICTSIVAED KKGHLIHGRN MDFGVFLGWN INNDTWVITE QLKPLTVNLD FQRNNKTVFK ASSFAGYVGM LTGFKPGLFS LTLNERFSIN GGYLGILEWI LGKKDVMWIG FLTRTVLENS TSYEEAKNLL TKTKILAPAY FILGGNQSGE GCVITRDRKE SLDVYELDAK QGRWYVVQTN YDRWKHPFFL DDRRTPAKMC LNRTSQENIS FETMYDVLST KPVLNKLTVY TTLIDVTKGQ FETYLRDCPD PCIGW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards