About Calcium/calmodulin-dependent protein kinase type II subunit beta
Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B) is a protein
from Homo sapiens identified by UniProt accession
Q13554, 666 residues long.
MolForge cross-references it against 0 known binders and
177 disease associations.
Target properties
| Protein name | Calcium/calmodulin-dependent protein kinase type II subunit beta |
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| UniProt accession | Q13554 |
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| Gene | CAMK2B |
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| Organism | Homo sapiens |
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| Length | 666 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (177)
Diseases linked to this target (Open Targets).
- intellectual disability, autosomal dominant 54 · score 0.77
- Intellectual disability · score 0.65
- genetic disorder · score 0.45
- vital capacity · score 0.37
- autosomal dominant non-syndromic intellectual disability · score 0.37
- Abnormality of the nervous system · score 0.34
- HbA1c measurement · score 0.33
- thyroid gland adenocarcinoma · score 0.30
- Global developmental delay · score 0.26
- Microcephaly · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13554-F1 | alphafold | PREDICTED | 70.55 | — |
Amino-acid sequence (666 residues)
MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL KGAILTTMLA TRNFSVGRQT TAPATMSTAA SGTTMGLVEQ AKSLLNKKAD GVKPQTNSTK NSAAATSPKG TLPPAALEPQ TTVIHNPVDG IKESSDSANT TIEDEDAKAP RVPDILSSVR RGSGAPEAEG PLPCPSPAPF SPLPAPSPRI SDILNSVRRG SGTPEAEGPL SAGPPPCLSP ALLGPLSSPS PRISDILNSV RRGSGTPEAE GPSPVGPPPC PSPTIPGPLP TPSRKQEIIK TTEQLIEAVN NGDFEAYAKI CDPGLTSFEP EALGNLVEGM DFHRFYFENL LAKNSKPIHT TILNPHVHVI GEDAACIAYI RLTQYIDGQG RPRTSQSEET RVWHRRDGKW QNVHFHCSGA PVAPLQ
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