Inositol-tetrakisphosphate 1-kinase (ITPK1)

About Inositol-tetrakisphosphate 1-kinase

Inositol-tetrakisphosphate 1-kinase (ITPK1) is a protein from Homo sapiens identified by UniProt accession Q13572, 414 residues long. MolForge cross-references it against 0 known binders and 111 disease associations.

Target properties

Protein name	Inositol-tetrakisphosphate 1-kinase
UniProt accession	Q13572
Gene	ITPK1
Organism	Homo sapiens
Length	414 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (111)

Diseases linked to this target (Open Targets).

platelet count · score 0.47
leukocyte count · score 0.43
protein measurement · score 0.43
forced expiratory volume · score 0.42
monocyte count · score 0.41
FEV/FVC ratio · score 0.41
platelet crit · score 0.41
chronic obstructive pulmonary disease · score 0.41
neurodegenerative disease · score 0.40
smoking status measurement · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13572-F1	alphafold	PREDICTED	83.02	—

Amino-acid sequence (414 residues)

MQTFLKGKRV GYWLSEKKIK KLNFQAFAEL CRKRGMEVVQ LNLSRPIEEQ GPLDVIIHKL TDVILEADQN DSQSLELVHR FQEYIDAHPE TIVLDPLPAI RTLLDRSKSY ELIRKIEAYM EDDRICSPPF MELTSLCGDD TMRLLEKNGL TFPFICKTRV AHGTNSHEMA IVFNQEGLNA IQPPCVVQNF INHNAVLYKV FVVGESYTVV QRPSLKNFSA GTSDRESIFF NSHNVSKPES SSVLTELDKI EGVFERPSDE VIRELSRALR QALGVSLFGI DIIINNQTGQ HAVIDINAFP GYEGVSEFFT DLLNHIATVL QGQSTAMAAT GDVALLRHSK LLAEPAGGLV GERTCSASPG CCGSMMGQDA PWKAEADAGG TAKLPHQRLG CNAGVSPSFQ QHCVASLATK ASSQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards