About Stromal interaction molecule 1
Stromal interaction molecule 1 (STIM1) is a protein
from Homo sapiens identified by UniProt accession
Q13586, 685 residues long.
MolForge cross-references it against 0 known binders and
663 disease associations.
Target properties
| Protein name | Stromal interaction molecule 1 |
|---|
| UniProt accession | Q13586 |
|---|
| Gene | STIM1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 685 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (663)
Diseases linked to this target (Open Targets).
- myopathy, tubular aggregate, 1 · score 0.78
- combined immunodeficiency due to STIM1 deficiency · score 0.77
- Stormorken syndrome · score 0.73
- tubular aggregate myopathy · score 0.68
- Stormorken-Sjaastad-Langslet syndrome · score 0.55
- combined immunodeficiency due to CRAC channel dysfunction · score 0.55
- combined immunodeficiency · score 0.46
- Combined immunodeficiency · score 0.46
- T-B+ severe combined immunodeficiency · score 0.46
- mean platelet volume · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13586-F1 | alphafold | PREDICTED | 67.81 | — |
Amino-acid sequence (685 residues)
MDVCVRLALW LLWGLLLHQG QSLSHSHSEK ATGTSSGANS EESTAAEFCR IDKPLCHSED EKLSFEAVRN IHKLMDDDAN GDVDVEESDE FLREDLNYHD PTVKHSTFHG EDKLISVEDL WKAWKSSEVY NWTVDEVVQW LITYVELPQY EETFRKLQLS GHAMPRLAVT NTTMTGTVLK MTDRSHRQKL QLKALDTVLF GPPLLTRHNH LKDFMLVVSI VIGVGGCWFA YIQNRYSKEH MKKMMKDLEG LHRAEQSLHD LQERLHKAQE EHRTVEVEKV HLEKKLRDEI NLAKQEAQRL KELREGTENE RSRQKYAEEE LEQVREALRK AEKELESHSS WYAPEALQKW LQLTHEVEVQ YYNIKKQNAE KQLLVAKEGA EKIKKKRNTL FGTFHVAHSS SLDDVDHKIL TAKQALSEVT AALRERLHRW QQIEILCGFQ IVNNPGIHSL VAALNIDPSW MGSTRPNPAH FIMTDDVDDM DEEIVSPLSM QSPSLQSSVR QRLTEPQHGL GSQRDLTHSD SESSLHMSDR QRVAPKPPQM SRAADEALNA MTSNGSHRLI EGVHPGSLVE KLPDSPALAK KALLALNHGL DKAHSLMELS PSAPPGGSPH LDSSRSHSPS SPDPDTPSPV GDSRALQASR NTRIPHLAGK KAVAEEDNGS IGEETDSSPG RKKFPLKIFK KPLKK
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