About BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1) is a protein
from Homo sapiens identified by UniProt accession
Q13829, 316 residues long.
MolForge cross-references it against 0 known binders and
91 disease associations.
Target properties
| Protein name | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 |
|---|
| UniProt accession | Q13829 |
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| Gene | TNFAIP1 |
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| Organism | Homo sapiens |
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| Length | 316 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (91)
Diseases linked to this target (Open Targets).
- vascular endothelial growth factor A measurement · score 0.11
- age-related macular degeneration · score 0.09
- atrophic macular degeneration · score 0.09
- wet macular degeneration · score 0.09
- blood protein measurement · score 0.08
- hepatocellular carcinoma · score 0.08
- macrophage scavenger receptor types I and II measurement · score 0.08
- breast cancer anti-estrogen resistance protein 3 measurement · score 0.08
- non-receptor tyrosine-protein kinase TYK2 measurement · score 0.08
- sporadic amyotrophic lateral sclerosis · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13829-F1 | alphafold | PREDICTED | 80.96 | — |
Amino-acid sequence (316 residues)
MSGDTCLCPA SGAKPKLSGF KGGGLGNKYV QLNVGGSLYY TTVRALTRHD TMLKAMFSGR MEVLTDKEGW ILIDRCGKHF GTILNYLRDD TITLPQNRQE IKELMAEAKY YLIQGLVNMC QSALQDKKDS YQPVCNIPII TSLKEEERLI ESSTKPVVKL LYNRSNNKYS YTSNSDDHLL KNIELFDKLS LRFNGRVLFI KDVIGDEICC WSFYGQGRKL AEVCCTSIVY ATEKKQTKVE FPEARIYEET LNVLLYETPR VPDNSLLEAT SRSRSQASPS EDEETFELRD RVRRIHVKRY STYDDRQLGH QSTHRD
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