About Glutathione hydrolase light chain 2
Glutathione hydrolase light chain 2 (GGTLC2) is a protein
from Homo sapiens identified by UniProt accession
Q14390, 218 residues long.
MolForge cross-references it against 0 known binders and
179 disease associations.
Target properties
| Protein name | Glutathione hydrolase light chain 2 |
|---|
| UniProt accession | Q14390 |
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| Gene | GGTLC2 |
|---|
| Organism | Homo sapiens |
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| Length | 218 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (179)
Diseases linked to this target (Open Targets).
- Thyrotoxicosis · score 0.32
- visual perception measurement · score 0.23
- Graves disease · score 0.23
- goiter · score 0.23
- 46,XX gonadal dysgenesis · score 0.05
- multiple epiphyseal dysplasia, with severe proximal femoral dysplasia · score 0.05
- hypogonadotropic hypogonadism · score 0.05
- Kallmann syndrome · score 0.05
- multiple epiphyseal dysplasia · score 0.05
- multiple epiphyseal dysplasia type 4 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14390-F1 | alphafold | PREDICTED | 89.92 | — |
Amino-acid sequence (218 residues)
MTSEFFAAQL RAQISDDTTH PISYYKPEFY TPVDGGTAHL SVVAEDGSAV SATSTINLYF GSKVRSPVSE ILFNDEMDDF SSPNITNEFG VPPSPANFIQ PGKQPLSSMC PTIMVGQDGQ PPSHADHTPM PQAIIYNLWF GYDVKRAVEE PRLHNQLLPN VTTVERNIDQ AVTAALETRH HHTQIASTFI AVVQAIVRTA GGWAAASDSR KGGEPAGY
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