About Squalene monooxygenase
Squalene monooxygenase (SQLE) is a protein
from Homo sapiens identified by UniProt accession
Q14534, 574 residues long.
MolForge cross-references it against 0 known binders and
141 disease associations.
Target properties
| Protein name | Squalene monooxygenase |
|---|
| UniProt accession | Q14534 |
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| Gene | SQLE |
|---|
| Organism | Homo sapiens |
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| Length | 574 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (141)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- Alzheimer disease · score 0.44
- lysosomal storage disease · score 0.43
- Parkinson disease · score 0.43
- multiple sclerosis · score 0.43
- platelet count · score 0.32
- electrocardiography · score 0.29
- hematocrit · score 0.29
- left ventricular structural measurement · score 0.29
- platelet crit · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14534-F1 | alphafold | PREDICTED | 85.84 | — |
Amino-acid sequence (574 residues)
MWTFLGIATF TYFYKKFGDF ITLANREVLL CVLVFLSLGL VLSYRCRHRN GGLLGRQQSG SQFALFSDIL SGLPFIGFFW AKSPPESENK EQLEARRRRK GTNISETSLI GTAACTSTSS QNDPEVIIVG AGVLGSALAA VLSRDGRKVT VIERDLKEPD RIVGEFLQPG GYHVLKDLGL GDTVEGLDAQ VVNGYMIHDQ ESKSEVQIPY PLSENNQVQS GRAFHHGRFI MSLRKAAMAE PNAKFIEGVV LQLLEEDDVV MGVQYKDKET GDIKELHAPL TVVADGLFSK FRKSLVSNKV SVSSHFVGFL MKNAPQFKAN HAELILANPS PVLIYQISSS ETRVLVDIRG EMPRNLREYM VEKIYPQIPD HLKEPFLEAT DNSHLRSMPA SFLPPSSVKK RGVLLLGDAY NMRHPLTGGG MTVAFKDIKL WRKLLKGIPD LYDDAAIFEA KKSFYWARKT SHSFVVNILA QALYELFSAT DDSLHQLRKA CFLYFKLGGE CVAGPVGLLS VLSPNPLVLI GHFFAVAIYA VYFCFKSEPW ITKPRALLSS GAVLYKACSV IFPLIYSEMK YMVH
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