ELAV-like protein 3 (ELAVL3)

About ELAV-like protein 3

ELAV-like protein 3 (ELAVL3) is a protein from Homo sapiens identified by UniProt accession Q14576, 367 residues long. MolForge cross-references it against 0 known binders and 135 disease associations.

Target properties

Protein name	ELAV-like protein 3
UniProt accession	Q14576
Gene	ELAVL3
Organism	Homo sapiens
Length	367 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (135)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
diastolic blood pressure · score 0.13
generalised epilepsy · score 0.09
autism spectrum disorder · score 0.09
juvenile myoclonic epilepsy · score 0.09
Generalized epilepsy with febrile seizures-plus · score 0.09
temporal lobe epilepsy · score 0.08
benign occipital epilepsy · score 0.08
childhood absence epilepsy · score 0.08
autosomal dominant epilepsy with auditory features · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14576-F1	alphafold	PREDICTED	75.49	—

Amino-acid sequence (367 residues)

MVTQILGAME SQVGGGPAGP ALPNGPLLGT NGATDDSKTN LIVNYLPQNM TQDEFKSLFG SIGDIESCKL VRDKITGQSL GYGFVNYSDP NDADKAINTL NGLKLQTKTI KVSYARPSSA SIRDANLYVS GLPKTMSQKE MEQLFSQYGR IITSRILVDQ VTGVSRGVGF IRFDKRIEAE EAIKGLNGQK PLGAAEPITV KFANNPSQKT GQALLTHLYQ SSARRYAGPL HHQTQRFRLD NLLNMAYGVK SPLSLIARFS PIAIDGMSGL AGVGLSGGAA GAGWCIFVYN LSPEADESVL WQLFGPFGAV TNVKVIRDFT TNKCKGFGFV TMTNYDEAAM AIASLNGYRL GERVLQVSFK TSKQHKA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards