About Transmembrane protein 187
Transmembrane protein 187 (TMEM187) is a protein
from Homo sapiens identified by UniProt accession
Q14656, 261 residues long.
MolForge cross-references it against 0 known binders and
13 disease associations.
Target properties
| Protein name | Transmembrane protein 187 |
|---|
| UniProt accession | Q14656 |
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| Gene | TMEM187 |
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| Organism | Homo sapiens |
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| Length | 261 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (13)
Diseases linked to this target (Open Targets).
- autoimmune lymphoproliferative syndrome type 2B · score 0.04
- Autoimmune lymphoproliferative syndrome with recurrent viral infections · score 0.04
- Rheumatoid arthritis · score 0.03
- Red cell distribution width · score 0.03
- Autism · score 0.02
- Systemic lupus erythematosus · score 0.01
- celiac disease · score 0.01
- cystic fibrosis · score 0.00
- osteoporosis-pseudoglioma syndrome · score 0.00
- neoplasm · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14656-F1 | alphafold | PREDICTED | 92.05 | — |
Amino-acid sequence (261 residues)
MNPEWGQAFV HVAVAGGLCA VAVFTGIFDS VSVQVGYEHY AEAPVAGLPA FLAMPFNSLV NMAYTLLGLS WLHRGGAMGL GPRYLKDVFA AMALLYGPVQ WLRLWTQWRR AAVLDQWLTL PIFAWPVAWC LYLDRGWRPW LFLSLECVSL ASYGLALLHP QGFEVALGAH VVAAVGQALR THRHYGSTTS ATYLALGVLS CLGFVVLKLC DHQLARWRLF QCLTGHFWSK VCDVLQFHFA FLFLTHFNTH PRFHPSGGKT R
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