DNA replication complex GINS protein PSF1 (GINS1)

About DNA replication complex GINS protein PSF1

DNA replication complex GINS protein PSF1 (GINS1) is a protein from Homo sapiens identified by UniProt accession Q14691, 196 residues long. MolForge cross-references it against 0 known binders and 132 disease associations.

Target properties

Protein name	DNA replication complex GINS protein PSF1
UniProt accession	Q14691
Gene	GINS1
Organism	Homo sapiens
Length	196 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (132)

Diseases linked to this target (Open Targets).

combined immunodeficiency due to GINS1 deficiency · score 0.70
fetal growth restriction · score 0.46
Polyneuropathy - hearing loss - ataxia - retinitis pigmentosa - cataract · score 0.45
PHARC syndrome · score 0.45
serum alanine aminotransferase measurement · score 0.28
phosphatidylinositol measurement · score 0.24
phosphatidylcholine measurement · score 0.24
protein measurement · score 0.20
mean corpuscular volume · score 0.18
body fat percentage · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14691-F1	alphafold	PREDICTED	93.03	—

Amino-acid sequence (196 residues)

MFCEKAMELI RELHRAPEGQ LPAFNEDGLR QVLEEMKALY EQNQSDVNEA KSGGRSDLIP TIKFRHCSLL RNRRCTVAYL YDRLLRIRAL RWEYGSVLPN ALRFHMAAEE MEWFNNYKRS LATYMRSLGG DEGLDITQDM KPPKSLYIEV RCLKDYGEFE VDDGTSVLLK KNSQHFLPRW KCEQLIRQGV LEHILS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards