About Sarcospan
Sarcospan (SSPN) is a protein
from Homo sapiens identified by UniProt accession
Q14714, 243 residues long.
MolForge cross-references it against 0 known binders and
138 disease associations.
Target properties
| Protein name | Sarcospan |
|---|
| UniProt accession | Q14714 |
|---|
| Gene | SSPN |
|---|
| Organism | Homo sapiens |
|---|
| Length | 243 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (138)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist-hip ratio · score 0.48
- physical activity measurement · score 0.47
- BMI-adjusted waist circumference · score 0.46
- reticulocyte count · score 0.45
- lymphocyte count · score 0.45
- high density lipoprotein cholesterol measurement · score 0.45
- atrial fibrillation · score 0.45
- triglyceride measurement · score 0.44
- heel bone mineral density · score 0.44
- waist-hip ratio · score 0.44
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14714-F1 | alphafold | PREDICTED | 74.07 | — |
Amino-acid sequence (243 residues)
MGKNKQPRGQ QRQGGPPAAD AAGPDDMEPK KGTGAPKECG EEEPRTCCGC RFPLLLALLQ LALGIAVTVV GFLMASISSS LLVRDTPFWA GIIVCLVAYL GLFMLCVSYQ VDERTCIQFS MKLLYFLLSA LGLTVCVLAV AFAAHHYSQL TQFTCETTLD SCQCKLPSSE PLSRTFVYRD VTDCTSVTGT FKLFLLIQMI LNLVCGLVCL LACFVMWKHR YQVFYVGVRI CSLTASEGPQ QKI
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