About Chromobox protein homolog 2
Chromobox protein homolog 2 (CBX2) is a protein
from Homo sapiens identified by UniProt accession
Q14781, 532 residues long.
MolForge cross-references it against 0 known binders and
162 disease associations.
Target properties
| Protein name | Chromobox protein homolog 2 |
|---|
| UniProt accession | Q14781 |
|---|
| Gene | CBX2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 532 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (162)
Diseases linked to this target (Open Targets).
- 46,XY complete gonadal dysgenesis · score 0.53
- glioblastoma multiforme · score 0.27
- breast adenocarcinoma · score 0.26
- endometrial cancer · score 0.25
- lung adenocarcinoma · score 0.21
- neurodegenerative disease · score 0.19
- head and neck squamous cell carcinoma · score 0.19
- disorder of sexual differentiation · score 0.14
- small cell lung carcinoma · score 0.14
- Genetic 46,XY disorder of sex development · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14781-F1 | alphafold | PREDICTED | 55.75 | — |
Amino-acid sequence (532 residues)
MEELSSVGEQ VFAAECILSK RLRKGKLEYL VKWRGWSSKH NSWEPEENIL DPRLLLAFQK KEHEKEVQNR KRGKRPRGRP RKLTAMSSCS RRSKLKEPDA PSKSKSSSSS SSSTSSSSSS DEEDDSDLDA KRGPRGRETH PVPQKKAQIL VAKPELKDPI RKKRGRKPLP PEQKATRRPV SLAKVLKTAR KDLGAPASKL PPPLSAPVAG LAALKAHAKE ACGGPSAMAT PENLASLMKG MASSPGRGGI SWQSSIVHYM NRMTQSQAQA ASRLALKAQA TNKCGLGLDL KVRTQKGELG MSPPGSKIPK APSGGAVEQK VGNTGGPPHT HGASRVPAGC PGPQPAPTQE LSLQVLDLQS VKNGMPGVGL LARHATATKG VPATNPAPGK GTGSGLIGAS GATMPTDTSK SEKLASRAVA PPTPASKRDC VKGSATPSGQ ESRTAPGEAR KAATLPEMSA GEESSSSDSD PDSASPPSTG QNPSVSVQTS QDWKPTRSLI EHVFVTDVTA NLITVTVKES PTSVGFFNLR HY
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