StAR-related lipid transfer protein 3 (STARD3)

About StAR-related lipid transfer protein 3

StAR-related lipid transfer protein 3 (STARD3) is a protein from Homo sapiens identified by UniProt accession Q14849, 445 residues long. MolForge cross-references it against 0 known binders and 131 disease associations.

Target properties

Protein name	StAR-related lipid transfer protein 3
UniProt accession	Q14849
Gene	STARD3
Organism	Homo sapiens
Length	445 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (131)

Diseases linked to this target (Open Targets).

high density lipoprotein cholesterol measurement · score 0.30
alcohol consumption measurement · score 0.24
apolipoprotein A 1 measurement · score 0.24
alcohol drinking · score 0.22
self reported educational attainment · score 0.21
total cholesterol measurement · score 0.20
triglyceride measurement · score 0.18
smoking status measurement · score 0.18
hematocrit · score 0.18
refractive error · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14849-F1	alphafold	PREDICTED	81.39	—

Amino-acid sequence (445 residues)

MSKLPRELTR DLERSLPAVA SLGSSLSHSQ SLSSHLLPPP EKRRAISDVR RTFCLFVTFD LLFISLLWII ELNTNTGIRK NLEQEIIQYN FKTSFFDIFV LAFFRFSGLL LGYAVLRLRH WWVIAVTTLV SSAFLIVKVI LSELLSKGAF GYLLPIVSFV LAWLETWFLD FKVLPQEAEE ERWYLAAQVA VARGPLLFSG ALSEGQFYSP PESFAGSDNE SDEEVAGKKS FSAQEREYIR QGKEATAVVD QILAQEENWK FEKNNEYGDT VYTIEVPFHG KTFILKTFLP CPAELVYQEV ILQPERMVLW NKTVTACQIL QRVEDNTLIS YDVSAGAAGG VVSPRDFVNV RRIERRRDRY LSSGIATSHS AKPPTHKYVR GENGPGGFIV LKSASNPRVC TFVWILNTDL KGRLPRYLIH QSLAATMFEF AFHLRQRISE LGARA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards