Hepatic sodium/bile acid cotransporter (SLC10A1)

About Hepatic sodium/bile acid cotransporter

Hepatic sodium/bile acid cotransporter (SLC10A1) is a protein from Homo sapiens identified by UniProt accession Q14973, 349 residues long. MolForge cross-references it against 0 known binders and 121 disease associations.

Target properties

Protein name	Hepatic sodium/bile acid cotransporter
UniProt accession	Q14973
Gene	SLC10A1
Organism	Homo sapiens
Length	349 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (12)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (121)

Diseases linked to this target (Open Targets).

hypercholanemia, familial, 2 · score 0.70
hepatitis D virus infection · score 0.41
viral disease · score 0.38
hypercholanemia, familial · score 0.37
chronic hepatitis · score 0.28
cutaneous melanoma · score 0.15
hepatitis B virus infection · score 0.12
hemoglobin measurement · score 0.12
chronic hepatitis B virus infection · score 0.11
hepatocellular carcinoma · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14973-F1	alphafold	PREDICTED	83.50	—

Amino-acid sequence (349 residues)

MEAHNASAPF NFTLPPNFGK RPTDLALSVI LVFMLFFIML SLGCTMEFSK IKAHLWKPKG LAIALVAQYG IMPLTAFVLG KVFRLKNIEA LAILVCGCSP GGNLSNVFSL AMKGDMNLSI VMTTCSTFCA LGMMPLLLYI YSRGIYDGDL KDKVPYKGIV ISLVLVLIPC TIGIVLKSKR PQYMRYVIKG GMIIILLCSV AVTVLSAINV GKSIMFAMTP LLIATSSLMP FIGFLLGYVL SALFCLNGRC RRTVSMETGC QNVQLCSTIL NVAFPPEVIG PLFFFPLLYM IFQLGEGLLL IAIFWCYEKF KTPKDKTKMI YTAATTEETI PGALGNGTYK GEDCSPCTA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards