About Transmembrane protein 132D
Transmembrane protein 132D (TMEM132D) is a protein
from Homo sapiens identified by UniProt accession
Q14C87, 1099 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | Transmembrane protein 132D |
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| UniProt accession | Q14C87 |
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| Gene | TMEM132D |
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| Organism | Homo sapiens |
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| Length | 1099 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (45)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.38
- bursitis · score 0.32
- Varicose veins · score 0.31
- drug use measurement · score 0.23
- Myopia · score 0.16
- central nervous system cancer · score 0.05
- panic disorder · score 0.04
- balding measurement · score 0.04
- hair shape measurement · score 0.03
- cortical thickness · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14C87-F1 | alphafold | PREDICTED | 70.41 | — |
Amino-acid sequence (1099 residues)
MCPSEMGTLW HHWSPVLISL AALFSKVTEG RGILESIQRF SLLPTYLPVT YHINNADVSF FLKEANQDIM RNSSLQSRVE SFLIYKSRRL PVLNASYGPF SIEQVVPQDL MLPSNPFGFT NKFSLNWKLK AHILRDKVYL SRPKVQVLFH IMGRDWDDRS AGEKLPCLRV FAFRETREVR GSCRLQGDLG LCVAELELLS SWFSPPTVVA GRRKSVDQPE GTPVELYYTV HPGGERGDCV REDARRSNGI RTGHSDIDES GPPLQRIGSI FLYQTHRKPS LRELRLDNSV AIHYIPKTVR KGDVLTFPVS ISRNSTEDRF TLRAKVKKGV NIIGVRASSP SIWDVKERTD YTGKYAPAVI VCQKKAAGSE NSADGASYEV MQIDVEVEEP GDLPATQLVT WQVEYPGEIT SDLGVSKIYV SPKDLIGVVP LAMEAEILNT AILTGKTVAV PVKVVSVEDD GTVTELLESV ECRSSDEDVI KVSDRCDYVF VNGKEMKGKV NVVVNFTYQH LSSPLEMTVW VPRLPLQIEV SDTELNQIKG WRVPIVSSRR PAGDSEEEED DERRGRGCTL QYQHAMVRVL TQFVAEAAGP GGHLAHLLGS DWQVDITELI NDFMQVEEPR IAKLQGGQIL MGQELGMTTI QILSPLSDTI LAEKTITVLD EKVTITDLGV QLVTGLSLSL QLSPGSNRAI FATAVAQELL QRPKQEAAIS CWVQFSDGSV TPLDIYDGKD FSLMATSLDE KVVSIHQDPK FKWPIIAAET EGQGTLVKVE MVISESCQKS KRKSVLAVGT ANIKVKFGQN DANPNTSDSR HTGAGVHMEN NVSDRRPKKP SQEWGSQEGQ YYGSSSMGLM EGRGTTTDRS ILQKKKGQES LLDDNSHLQT IPSDLTSFPA QVDLPRSNGE MDGNDLMQAS KGLSDLEIGM YALLGVFCLA ILVFLINCVT FALKYRHKQV PFEEQEGMSH SHDWVGLSNR TELLENHINF ASSQDEQITA IDRGMDFEES KYLLSTNSQK SINGQLFKPL GPIIIDGKDQ KSEPPTSPTS KRKRVKFTTF TAVSSDDEYP TRNSIVMSSE DDIKWVCQDL DPGDCKELHN YMERLHENV
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