About Lysine--tRNA ligase
Lysine--tRNA ligase (KARS1) is a protein
from Homo sapiens identified by UniProt accession
Q15046, 597 residues long.
MolForge cross-references it against 0 known binders and
214 disease associations.
Target properties
| Protein name | Lysine--tRNA ligase |
|---|
| UniProt accession | Q15046 |
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| Gene | KARS1 |
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| Organism | Homo sapiens |
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| Length | 597 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (214)
Diseases linked to this target (Open Targets).
- leukoencephalopathy, progressive, infantile-onset, with or without deafness · score 0.74
- deafness, congenital, and adult-onset progressive leukoencephalopathy · score 0.72
- autosomal recessive nonsyndromic hearing loss 89 · score 0.64
- Charcot-Marie-Tooth disease recessive intermediate B · score 0.60
- Autosomal recessive intermediate Charcot-Marie-Tooth disease type B · score 0.55
- deafness · score 0.52
- Global developmental delay · score 0.46
- sensorineural hearing loss · score 0.42
- Sensorineural hearing impairment · score 0.42
- Optic neuropathy · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15046-F1 | alphafold | PREDICTED | 90.53 | — |
Amino-acid sequence (597 residues)
MAAVQAAEVK VDGSEPKLSK NELKRRLKAE KKVAEKEAKQ KELSEKQLSQ ATAAATNHTT DNGVGPEEES VDPNQYYKIR SQAIHQLKVN GEDPYPHKFH VDISLTDFIQ KYSHLQPGDH LTDITLKVAG RIHAKRASGG KLIFYDLRGE GVKLQVMANS RNYKSEEEFI HINNKLRRGD IIGVQGNPGK TKKGELSIIP YEITLLSPCL HMLPHLHFGL KDKETRYRQR YLDLILNDFV RQKFIIRSKI ITYIRSFLDE LGFLEIETPM MNIIPGGAVA KPFITYHNEL DMNLYMRIAP ELYHKMLVVG GIDRVYEIGR QFRNEGIDLT HNPEFTTCEF YMAYADYHDL MEITEKMVSG MVKHITGSYK VTYHPDGPEG QAYDVDFTPP FRRINMVEEL EKALGMKLPE TNLFETEETR KILDDICVAK AVECPPPRTT ARLLDKLVGE FLEVTCINPT FICDHPQIMS PLAKWHRSKE GLTERFELFV MKKEICNAYT ELNDPMRQRQ LFEEQAKAKA AGDDEAMFID ENFCTALEYG LPPTAGWGMG IDRVAMFLTD SNNIKEVLLF PAMKPEDKKE NVATTDTLES TTVGTSV
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