About Platelet-derived growth factor receptor-like protein
Platelet-derived growth factor receptor-like protein (PDGFRL) is a protein
from Homo sapiens identified by UniProt accession
Q15198, 375 residues long.
MolForge cross-references it against 0 known binders and
98 disease associations.
Target properties
| Protein name | Platelet-derived growth factor receptor-like protein |
|---|
| UniProt accession | Q15198 |
|---|
| Gene | PDGFRL |
|---|
| Organism | Homo sapiens |
|---|
| Length | 375 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (98)
Diseases linked to this target (Open Targets).
- colorectal neoplasm · score 0.37
- neurodegenerative disease · score 0.37
- colorectal cancer · score 0.37
- colorectal adenocarcinoma · score 0.37
- colon carcinoma · score 0.33
- amino acid measurement · score 0.26
- L-arginine measurement · score 0.23
- metabolite measurement · score 0.22
- hippocampal volume · score 0.21
- ornithine measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15198-F1 | alphafold | PREDICTED | 83.64 | — |
Amino-acid sequence (375 residues)
MKVWLLLGLL LVHEALEDVT GQHLPKNKRP KEPGENRIKP TNKKVKPKIP KMKDRDSANS APKTQSIMMQ VLDKGRFQKP AATLSLLAGQ TVELRCKGSR IGWSYPAYLD TFKDSRLSVK QNERYGQLTL VNSTSADTGE FSCWVQLCSG YICRKDEAKT GSTYIFFTEK GELFVPSPSY FDVVYLNPDR QAVVPCRVTV LSAKVTLHRE FPAKEIPANG TDIVYDMKRG FVYLQPHSEH QGVVYCRAEA GGRSQISVKY QLLYVAVPSG PPSTTILASS NKVKSGDDIS VLCTVLGEPD VEVEFTWIFP GQKDERPVTI QDTWRLIHRG LGHTTRISQS VITVEDFETI DAGYYICTAQ NLQGQTTVAT TVEFS
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