Surfeit locus protein 2 (SURF2)

About Surfeit locus protein 2

Surfeit locus protein 2 (SURF2) is a protein from Homo sapiens identified by UniProt accession Q15527, 256 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.

Target properties

Protein name	Surfeit locus protein 2
UniProt accession	Q15527
Gene	SURF2
Organism	Homo sapiens
Length	256 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (19)

Diseases linked to this target (Open Targets).

alkaline phosphatase measurement · score 0.21
a disintegrin and metalloproteinase with thrombospondin motifs 13 measurement · score 0.11
neutrophil count · score 0.05
angiopoietin-1 receptor measurement · score 0.04
aspartate aminotransferase measurement · score 0.04
heel bone mineral density · score 0.04
total cholesterol measurement · score 0.04
apolipoprotein A 1 measurement · score 0.04
Back pain · score 0.04
lymphocyte percentage of leukocytes · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15527-F1	alphafold	PREDICTED	70.26	—

Amino-acid sequence (256 residues)

MSELPGDVRA FLREHPSLRL QTDARKVRCI LTGHELPCRL PELQVYTRGK KYQRLVRASP AFDYAEFEPH IVPSTKNPHQ LFCKLTLRHI NKCPEHVLRH TQGRRYQRAL CKYEECQKQG VEYVPACLVH RRRRREDQMD GDGPRPREAF WEPTSSDEGG AASDDSMTDL YPPELFTRKD LGSTEDGDGT DDFLTDKEDE KAKPPREKAT DEGRRETTVY RGLVQKRGKK QLGSLKKKFK SHHRKPKSFS SCKQPG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards