About Transforming growth factor-beta-induced protein ig-h3
Transforming growth factor-beta-induced protein ig-h3 (TGFBI) is a protein
from Homo sapiens identified by UniProt accession
Q15582, 683 residues long.
MolForge cross-references it against 0 known binders and
428 disease associations.
Target properties
| Protein name | Transforming growth factor-beta-induced protein ig-h3 |
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| UniProt accession | Q15582 |
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| Gene | TGFBI |
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| Organism | Homo sapiens |
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| Length | 683 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (428)
Diseases linked to this target (Open Targets).
- lattice corneal dystrophy type I · score 0.79
- granular corneal dystrophy type I · score 0.73
- Reis-Bucklers corneal dystrophy · score 0.70
- Reis-Bücklers corneal dystrophy · score 0.70
- epithelial basement membrane dystrophy · score 0.70
- granular corneal dystrophy type II · score 0.68
- Microcystic corneal dystrophy · score 0.67
- Thiel-Behnke corneal dystrophy · score 0.66
- epithelial-stromal TGFBI dystrophy · score 0.47
- AL amyloidosis · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15582-F1 | alphafold | PREDICTED | 90.24 | — |
Amino-acid sequence (683 residues)
MALFVRLLAL ALALALGPAA TLAGPAKSPY QLVLQHSRLR GRQHGPNVCA VQKVIGTNRK YFTNCKQWYQ RKICGKSTVI SYECCPGYEK VPGEKGCPAA LPLSNLYETL GVVGSTTTQL YTDRTEKLRP EMEGPGSFTI FAPSNEAWAS LPAEVLDSLV SNVNIELLNA LRYHMVGRRV LTDELKHGMT LTSMYQNSNI QIHHYPNGIV TVNCARLLKA DHHATNGVVH LIDKVISTIT NNIQQIIEIE DTFETLRAAV AASGLNTMLE GNGQYTLLAP TNEAFEKIPS ETLNRILGDP EALRDLLNNH ILKSAMCAEA IVAGLSVETL EGTTLEVGCS GDMLTINGKA IISNKDILAT NGVIHYIDEL LIPDSAKTLF ELAAESDVST AIDLFRQAGL GNHLSGSERL TLLAPLNSVF KDGTPPIDAH TRNLLRNHII KDQLASKYLY HGQTLETLGG KKLRVFVYRN SLCIENSCIA AHDKRGRYGT LFTMDRVLTP PMGTVMDVLK GDNRFSMLVA AIQSAGLTET LNREGVYTVF APTNEAFRAL PPRERSRLLG DAKELANILK YHIGDEILVS GGIGALVRLK SLQGDKLEVS LKNNVVSVNK EPVAEPDIMA TNGVVHVITN VLQPPANRPQ ERGDELADSA LEIFKQASAF SRASQRSVRL APVYQKLLER MKH
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