About TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a protein
from Homo sapiens identified by UniProt accession
Q15750, 504 residues long.
MolForge cross-references it against 0 known binders and
194 disease associations.
Target properties
| Protein name | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 |
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| UniProt accession | Q15750 |
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| Gene | TAB1 |
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| Organism | Homo sapiens |
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| Length | 504 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (194)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.46
- neuroinflammatory disorder · score 0.29
- glioblastoma multiforme · score 0.23
- low grade glioma · score 0.23
- neurodegenerative disease · score 0.22
- serum IgG glycosylation measurement · score 0.18
- lung adenocarcinoma · score 0.17
- von Willebrand factor measurement · score 0.15
- body height · score 0.15
- blood protein measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15750-F1 | alphafold | PREDICTED | 78.04 | — |
Amino-acid sequence (504 residues)
MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE DSWLKFRSEN NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNAEHAEA DVRRVLLQAF DVVERSFLES IDDALAEKAS LQSQLPEGVP QHQLPPQYQK ILERLKTLER EISGGAMAVV AVLLNNKLYV ANVGTNRALL CKSTVDGLQV TQLNVDHTTE NEDELFRLSQ LGLDAGKIKQ VGIICGQEST RRIGDYKVKY GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAR FCPRHEDMTL LVRNFGYPLG EMSQPTPSPA PAAGGRVYPV SVPYSSAQST SKTSVTLSLV MPSQGQMVNG AHSASTLDEA TPTLTNQSPT LTLQSTNTHT QSSSSSSDGG LFRSRPAHSL PPGEDGRVEP YVDFAEFYRL WSVDHGEQSV VTAP
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