Tubulin-specific chaperone C (TBCC)

About Tubulin-specific chaperone C

Tubulin-specific chaperone C (TBCC) is a protein from Homo sapiens identified by UniProt accession Q15814, 346 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.

Target properties

Protein name	Tubulin-specific chaperone C
UniProt accession	Q15814
Gene	TBCC
Organism	Homo sapiens
Length	346 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (72)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
lung adenocarcinoma · score 0.18
head and neck squamous cell carcinoma · score 0.18
breast adenocarcinoma · score 0.18
urinary bladder cancer · score 0.14
chronic lymphocytic leukemia · score 0.10
familial atrial fibrillation · score 0.08
Romano-Ward syndrome · score 0.07
Brugada syndrome · score 0.07
Familial short QT syndrome · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15814-F1	alphafold	PREDICTED	81.34	—

Amino-acid sequence (346 residues)

MESVSCSAAA VRTGDMESQR DLSLVPERLQ RREQERQLEV ERRKQKRQNQ EVEKENSHFF VATFVRERAA VEELLERAES VERLEEAASR LQGLQKLIND SVFFLAAYDL RQGQEALARL QAALAERRRG LQPKKRFAFK TRGKDAASST KVDAAPGIPP AVESIQDSPL PKKAEGDLGP SWVCGFSNLE SQVLEKRASE LHQRDVLLTE LSNCTVRLYG NPNTLRLTKA HSCKLLCGPV STSVFLEDCS DCVLAVACQQ LRIHSTKDTR IFLQVTSRAI VEDCSGIQFA PYTWSYPEID KDFESSGLDR SKNNWNDVDD FNWLARDMAS PNWSILPEEE RNIQWD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards