About Serine/threonine-protein kinase STK11
Serine/threonine-protein kinase STK11 (STK11) is a protein
from Homo sapiens identified by UniProt accession
Q15831, 433 residues long.
MolForge cross-references it against 0 known binders and
805 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase STK11 |
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| UniProt accession | Q15831 |
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| Gene | STK11 |
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| Organism | Homo sapiens |
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| Length | 433 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (805)
Diseases linked to this target (Open Targets).
- Peutz-Jeghers syndrome · score 0.87
- lung adenocarcinoma · score 0.71
- pancreatic neoplasm · score 0.65
- cutaneous melanoma · score 0.65
- melanoma, cutaneous malignant, susceptibility to, 1 · score 0.61
- pancreatic carcinoma · score 0.61
- non-small cell lung carcinoma · score 0.59
- hereditary neoplastic syndrome · score 0.58
- Inherited cancer-predisposing syndrome · score 0.57
- familial pancreatic carcinoma · score 0.57
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15831-F1 | alphafold | PREDICTED | 78.79 | — |
Amino-acid sequence (433 residues)
MEVVDPQQLG MFTEGELMSV GMDTFIHRID STEVIYQPRR KRAKLIGKYL MGDLLGEGSY GKVKEVLDSE TLCRRAVKIL KKKKLRRIPN GEANVKKEIQ LLRRLRHKNV IQLVDVLYNE EKQKMYMVME YCVCGMQEML DSVPEKRFPV CQAHGYFCQL IDGLEYLHSQ GIVHKDIKPG NLLLTTGGTL KISDLGVAEA LHPFAADDTC RTSQGSPAFQ PPEIANGLDT FSGFKVDIWS AGVTLYNITT GLYPFEGDNI YKLFENIGKG SYAIPGDCGP PLSDLLKGML EYEPAKRFSI RQIRQHSWFR KKHPPAEAPV PIPPSPDTKD RWRSMTVVPY LEDLHGADED EDLFDIEDDI IYTQDFTVPG QVPEEEASHN GQRRGLPKAV CMNGTEAAQL STKSRAEGRA PNPARKACSA SSKIRRLSAC KQQ
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