About ATP-sensitive inward rectifier potassium channel 8
ATP-sensitive inward rectifier potassium channel 8 (KCNJ8) is a protein
from Homo sapiens identified by UniProt accession
Q15842, 424 residues long.
MolForge cross-references it against 0 known binders and
309 disease associations.
Target properties
| Protein name | ATP-sensitive inward rectifier potassium channel 8 |
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| UniProt accession | Q15842 |
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| Gene | KCNJ8 |
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| Organism | Homo sapiens |
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| Length | 424 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (309)
Diseases linked to this target (Open Targets).
- hypertrichotic osteochondrodysplasia Cantu type · score 0.64
- Hypertrichotic osteochondrodysplasia, Cantu type · score 0.61
- type 1 diabetes mellitus · score 0.46
- sudden infant death syndrome · score 0.42
- type 2 diabetes mellitus · score 0.41
- hyperinsulinism · score 0.39
- hypertension · score 0.39
- Hypoglycemia · score 0.37
- digestive system neuroendocrine neoplasm · score 0.37
- pancreatic insulinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15842-F1 | alphafold | PREDICTED | 84.08 | — |
Amino-acid sequence (424 residues)
MLARKSIIPE EYVLARIAAE NLRKPRIRDR LPKARFIAKS GACNLAHKNI REQGRFLQDI FTTLVDLKWR HTLVIFTMSF LCSWLLFAIM WWLVAFAHGD IYAYMEKSGM EKSGLESTVC VTNVRSFTSA FLFSIEVQVT IGFGGRMMTE ECPLAITVLI LQNIVGLIIN AVMLGCIFMK TAQAHRRAET LIFSRHAVIA VRNGKLCFMF RVGDLRKSMI ISASVRIQVV KKTTTPEGEV VPIHQLDIPV DNPIESNNIF LVAPLIICHV IDKRSPLYDI SATDLANQDL EVIVILEGVV ETTGITTQAR TSYIAEEIQW GHRFVSIVTE EEGVYSVDYS KFGNTVKVAA PRCSARELDE KPSILIQTLQ KSELSHQNSL RKRNSMRRNN SMRRNNSIRR NNSSLMVPKV QFMTPEGNQN TSES
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