Levosimendan

CARDIOVASCULAR SYSTEM

Key facts

Levosimendan is a drug catalogued in DrugCentral. DrugCentral lists 4 molecular targets, including TNNC1, PDE3A and KCNJ11. Recorded indications include Congestive heart failure.

• Molecular targets: TNNC1, PDE3A, KCNJ11 and KCNJ8 (4 listed in DrugCentral).
• Indications: Congestive heart failure.
• ATC code: C01CX08 (Other cardiac stimulants).
• Molecular formula: C14H12N6O; molecular weight 280.29 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Congestive heart failure

Mechanism & targets

Molecular targets (4)

Target	Gene	Action	Activity
Troponin C, slow skeletal and cardiac muscles	TNNC1	opener	Kd 3.15
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	unknown	—
ATP-sensitive inward rectifier potassium channel 11	KCNJ11	unknown	—
ATP-sensitive inward rectifier potassium channel 8	KCNJ8	unknown	—

ATC classification

ATC code	Therapeutic hierarchy
C01CX08	CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES › Other cardiac stimulants

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Femoral hernia incarcerated	238.2
Lymphatic fistula	237.7
Wound infection pseudomonas	217.6
Pancreatic steatosis	215.0
Arterial haemorrhage	199.2
Seroma	193.2
Aortic valve stenosis	168.2
Haemarthrosis	164.9
Hepatic cyst	163.7
Tachyarrhythmia	158.9
Eructation	156.2
Diverticulum intestinal	155.1

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Levosimendan is on its molecule page.

• Molecular formula: C₁₄H₁₂N₆O
• Molecular weight: 280.29 g/mol
• CAS number: 141505-33-1
• InChIKey: WHXMKTBCFHIYNQ-SECBINFHSA-N
• PubChem CID: 3033825

C[C@@H]1CC(=O)NN=C1C1=CC=C(NN=C(C#N)C#N)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Levosimendan used for?

DrugCentral lists the following indications for Levosimendan: Congestive heart failure.

How does Levosimendan work?

Its molecular targets in DrugCentral include TNNC1 (opener), PDE3A, KCNJ11 and KCNJ8.

What is the chemical formula of Levosimendan?

Levosimendan has the molecular formula C14H12N6O and a molecular weight of 280.29 g/mol.

Sources

• DrugCentral drug card 1576 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2051955 — compound record and bioactivity
• PubChem CID 3033825 — chemical identifiers
• DrugBank DB00922 — drug record
• FDA UNII C6T4514L4E — substance identity
• UniProt P63316 (TNNC1) — target protein
• UniProt Q14432 (PDE3A) — target protein
• UniProt Q14654 (KCNJ11) — target protein
• UniProt Q15842 (KCNJ8) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.