About ATP-sensitive inward rectifier potassium channel 11
ATP-sensitive inward rectifier potassium channel 11 (KCNJ11) is a protein
from Homo sapiens identified by UniProt accession
Q14654, 390 residues long.
MolForge cross-references it against 0 known binders and
369 disease associations.
Target properties
| Protein name | ATP-sensitive inward rectifier potassium channel 11 |
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| UniProt accession | Q14654 |
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| Gene | KCNJ11 |
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| Organism | Homo sapiens |
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| Length | 390 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (369)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.86
- hyperinsulinemic hypoglycemia, familial, 2 · score 0.81
- diabetes mellitus, permanent neonatal 2 · score 0.81
- diabetes mellitus · score 0.78
- diabetes mellitus, transient neonatal, 3 · score 0.78
- MODY · score 0.66
- maturity-onset diabetes of the young type 13 · score 0.61
- permanent neonatal diabetes mellitus 1 · score 0.60
- permanent neonatal diabetes mellitus · score 0.59
- gestational diabetes · score 0.58
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14654-F1 | alphafold | PREDICTED | 83.78 | — |
Amino-acid sequence (390 residues)
MLSRKGIIPE EYVLTRLAED PAKPRYRARQ RRARFVSKKG NCNVAHKNIR EQGRFLQDVF TTLVDLKWPH TLLIFTMSFL CSWLLFAMAW WLIAFAHGDL APSEGTAEPC VTSIHSFSSA FLFSIEVQVT IGFGGRMVTE ECPLAILILI VQNIVGLMIN AIMLGCIFMK TAQAHRRAET LIFSKHAVIA LRHGRLCFML RVGDLRKSMI ISATIHMQVV RKTTSPEGEV VPLHQVDIPM ENGVGGNSIF LVAPLIIYHV IDANSPLYDL APSDLHHHQD LEIIVILEGV VETTGITTQA RTSYLADEIL WGQRFVPIVA EEDGRYSVDY SKFGNTVKVP TPLCTARQLD EDHSLLEALT LASARGPLRK RSVPMAKAKP KFSISPDSLS
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