Cibenzoline
CARDIOVASCULAR SYSTEM
Also known as: (+/-)-Cibenzoline, (RS)-Cibenzoline, cibenzoline succinate, cifenline, cifenline succinate
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Cibenzoline is a drug catalogued in DrugCentral. It was first approved by the YEAR INTRODUCED in 1978. DrugCentral lists 3 molecular targets, including KCNH2, HCN4 and KCNJ11.
- Molecular targets: KCNH2, HCN4 and KCNJ11 (3 listed in DrugCentral).
- ATC code: C01BG07 (Other antiarrhythmics, class I and III).
- Molecular formula: C18H18N2; molecular weight 262.36 g/mol.
Mechanism & targets
Molecular targets (3)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Potassium voltage-gated channel subfamily H member 2 | KCNH2 | unknown | IC50 5.06 |
| Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | HCN4 | unknown | IC50 4.33 |
| ATP-sensitive inward rectifier potassium channel 11 | KCNJ11 | unknown | — |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 1978-01-01 | YEAR INTRODUCED | — | — |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
C01BG07 | CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › ANTIARRHYTHMICS, CLASS I AND III › Other antiarrhythmics, class I and III |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Cibenzoline is on its molecule page.
| Molecular formula | C18H18N2 |
|---|---|
| Molecular weight | 262.36 g/mol |
| CAS number | 53267-01-9 |
| InChIKey | IPOBOOXFSRWSHL-UHFFFAOYSA-N |
| PubChem CID | 2747 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
How does Cibenzoline work?
Its molecular targets in DrugCentral include KCNH2, HCN4 and KCNJ11.
When was Cibenzoline first approved?
Cibenzoline was first approved by the YEAR INTRODUCED in 1978.
What is the chemical formula of Cibenzoline?
Cibenzoline has the molecular formula C18H18N2 and a molecular weight of 262.36 g/mol.
Browse: all drugs starting with C · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 630 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL2106074 — compound record and bioactivity
- PubChem CID 2747 — chemical identifiers
- DrugBank DB13358 — drug record
- FDA UNII Z7489237QT — substance identity
- UniProt Q12809 (KCNH2) — target protein
- UniProt Q9Y3Q4 (HCN4) — target protein
- UniProt Q14654 (KCNJ11) — target protein
How this page is built: methodology · editorial policy & corrections.
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