Troponin C, slow skeletal and cardiac muscles (TNNC1)

About Troponin C, slow skeletal and cardiac muscles

Troponin C, slow skeletal and cardiac muscles (TNNC1) is a protein from Homo sapiens identified by UniProt accession P63316, 161 residues long. MolForge cross-references it against 0 known binders and 246 disease associations.

Target properties

Protein name	Troponin C, slow skeletal and cardiac muscles
UniProt accession	P63316
Gene	TNNC1
Organism	Homo sapiens
Length	161 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (246)

Diseases linked to this target (Open Targets).

hypertrophic cardiomyopathy 13 · score 0.78
dilated cardiomyopathy 1Z · score 0.72
heart failure · score 0.58
Rare familial disorder with hypertrophic cardiomyopathy · score 0.55
hypertrophic cardiomyopathy · score 0.54
dilated cardiomyopathy · score 0.48
Dilated cardiomyopathy · score 0.46
neurodegenerative disease · score 0.44
cardiovascular disease · score 0.43
Acute kidney injury · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P63316-F1	alphafold	PREDICTED	79.88	—

Amino-acid sequence (161 residues)

MDDIYKAAVE QLTEEQKNEF KAAFDIFVLG AEDGCISTKE LGKVMRMLGQ NPTPEELQEM IDEVDEDGSG TVDFDEFLVM MVRCMKDDSK GKSEEELSDL FRMFDKNADG YIDLDELKIM LQATGETITE DDIEELMKDG DKNNDGRIDY DEFLEFMKGV E

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards