About Nuclear factor erythroid 2-related factor 2
Nuclear factor erythroid 2-related factor 2 (NFE2L2) is a protein
from Homo sapiens identified by UniProt accession
Q16236, 605 residues long.
MolForge cross-references it against 0 known binders and
1,171 disease associations.
Target properties
| Protein name | Nuclear factor erythroid 2-related factor 2 |
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| UniProt accession | Q16236 |
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| Gene | NFE2L2 |
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| Organism | Homo sapiens |
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| Length | 605 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (1171)
Diseases linked to this target (Open Targets).
- immunodeficiency, developmental delay, and hypohomocysteinemia · score 0.77
- hepatocellular carcinoma · score 0.65
- squamous cell lung carcinoma · score 0.64
- head and neck squamous cell carcinoma · score 0.54
- lung adenocarcinoma · score 0.47
- bladder transitional cell carcinoma · score 0.47
- sex hormone-binding globulin measurement · score 0.46
- papillary renal cell carcinoma · score 0.46
- urinary bladder cancer · score 0.44
- Friedreich ataxia · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16236-F1 | alphafold | PREDICTED | 60.54 | — |
Amino-acid sequence (605 residues)
MMDLELPPPG LPSQQDMDLI DILWRQDIDL GVSREVFDFS QRRKEYELEK QKKLEKERQE QLQKEQEKAF FAQLQLDEET GEFLPIQPAQ HIQSETSGSA NYSQVAHIPK SDALYFDDCM QLLAQTFPFV DDNEVSSATF QSLVPDIPGH IESPVFIATN QAQSPETSVA QVAPVDLDGM QQDIEQVWEE LLSIPELQCL NIENDKLVET TMVPSPEAKL TEVDNYHFYS SIPSMEKEVG NCSPHFLNAF EDSFSSILST EDPNQLTVNS LNSDATVNTD FGDEFYSAFI AEPSISNSMP SPATLSHSLS ELLNGPIDVS DLSLCKAFNQ NHPESTAEFN DSDSGISLNT SPSVASPEHS VESSSYGDTL LGLSDSEVEE LDSAPGSVKQ NGPKTPVHSS GDMVQPLSPS QGQSTHVHDA QCENTPEKEL PVSPGHRKTP FTKDKHSSRL EAHLTRDELR AKALHIPFPV EKIINLPVVD FNEMMSKEQF NEAQLALIRD IRRRGKNKVA AQNCRKRKLE NIVELEQDLD HLKDEKEKLL KEKGENDKSL HLLKKQLSTL YLEVFSMLRD EDGKPYSPSE YSLQQTRDGN VFLVPKSKKP DVKKN
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