Halofuginone

Drug profile

Key facts

Halofuginone is a drug catalogued in DrugCentral. DrugCentral lists 2 molecular targets, including proRS and NFE2L2.

• Molecular targets: proRS and NFE2L2 (2 listed in DrugCentral).
• Molecular formula: C16H17BrClN3O3; molecular weight 414.69 g/mol.

Mechanism & targets

Molecular targets (2)

Target	Gene	Action	Activity
Proline--tRNA ligase, PfPRS, EC 6.1.1.15	proRS	unknown	EC50 9.07
Nuclear factor erythroid 2-related factor 2	NFE2L2	unknown	IC50 7.65

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	—

Chemical structure

• Molecular formula: C₁₆H₁₇BrClN₃O₃
• Molecular weight: 414.69 g/mol
• CAS number: —
• InChIKey: LVASCWIMLIKXLA-CABCVRRESA-N
• PubChem CID: 456390

O[C@H]1CCCN[C@@H]1CC(=O)CN2C=NC3=CC(Br)=C(Cl)C=C3C2=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Halofuginone work?

Its molecular targets in DrugCentral include proRS and NFE2L2.

What is the chemical formula of Halofuginone?

Halofuginone has the molecular formula C16H17BrClN3O3 and a molecular weight of 414.69 g/mol.

Sources

• DrugCentral drug card 5553 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1162013 — compound record and bioactivity
• PubChem CID 456390 — chemical identifiers
• DrugBank DB04866 — drug record
• FDA UNII L31MM1385E — substance identity
• DailyMed: FDA labels for Halofuginone — current prescribing information (label search)
• UniProt Q16236 (NFE2L2) — target protein

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