Synaptophysin-like protein 1 (SYPL1)

About Synaptophysin-like protein 1

Synaptophysin-like protein 1 (SYPL1) is a protein from Homo sapiens identified by UniProt accession Q16563, 259 residues long. MolForge cross-references it against 0 known binders and 138 disease associations.

Target properties

Protein name	Synaptophysin-like protein 1
UniProt accession	Q16563
Gene	SYPL1
Organism	Homo sapiens
Length	259 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (138)

Diseases linked to this target (Open Targets).

multiple sclerosis · score 0.25
Intellectual disability · score 0.12
neutrophil count · score 0.11
susceptibility to childhood ear infection measurement · score 0.10
azoospermia · score 0.10
Abnormal mastoid morphology · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.08
metabolite measurement · score 0.08
non-suppurative otitis media · score 0.08
C-reactive protein measurement · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16563-F1	alphafold	PREDICTED	82.71	—

Amino-acid sequence (259 residues)

MAPNIYLVRQ RISRLGQRMS GFQINLNPLK EPLGFIKVLE WIASIFAFAT CGGFKGQTEI QVNCPPAVTE NKTVTATFGY PFRLNEASFQ PPPGVNICDV NWKDYVLIGD YSSSAQFYVT FAVFVFLYCI AALLLYVGYT SLYLDSRKLP MIDFVVTLVA TFLWLVSTSA WAKALTDIKI ATGHNIIDEL PPCKKKAVLC YFGSVTSMGS LNVSVIFGFL NMILWGGNAW FVYKETSLHS PSNTSAPHSQ GGIPPPTGI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards