About Syntaxin-1A
Syntaxin-1A (STX1A) is a protein
from Homo sapiens identified by UniProt accession
Q16623, 288 residues long.
MolForge cross-references it against 0 known binders and
204 disease associations.
Target properties
| Protein name | Syntaxin-1A |
|---|
| UniProt accession | Q16623 |
|---|
| Gene | STX1A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 288 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (204)
Diseases linked to this target (Open Targets).
- Intellectual disability · score 0.48
- autism · score 0.44
- cystic fibrosis · score 0.37
- botulism · score 0.37
- Seizure · score 0.37
- IGF-1 measurement · score 0.27
- triglyceride measurement · score 0.26
- cutaneous melanoma · score 0.18
- clear cell renal carcinoma · score 0.17
- genetic disorder · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16623-F1 | alphafold | PREDICTED | 84.74 | — |
Amino-acid sequence (288 residues)
MKDRTQELRT AKDSDDDDDV AVTVDRDRFM DEFFEQVEEI RGFIDKIAEN VEEVKRKHSA ILASPNPDEK TKEELEELMS DIKKTANKVR SKLKSIEQSI EQEEGLNRSS ADLRIRKTQH STLSRKFVEV MSEYNATQSD YRERCKGRIQ RQLEITGRTT TSEELEDMLE SGNPAIFASG IIMDSSISKQ ALSEIETRHS EIIKLENSIR ELHDMFMDMA MLVESQGEMI DRIEYNVEHA VDYVERAVSD TKKAVKYQSK ARRKKIMIII CCVILGIVIA STVGGIFA
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