About T-box brain protein 1
T-box brain protein 1 (TBR1) is a protein
from Homo sapiens identified by UniProt accession
Q16650, 682 residues long.
MolForge cross-references it against 0 known binders and
202 disease associations.
Target properties
| Protein name | T-box brain protein 1 |
|---|
| UniProt accession | Q16650 |
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| Gene | TBR1 |
|---|
| Organism | Homo sapiens |
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| Length | 682 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (202)
Diseases linked to this target (Open Targets).
- autism spectrum disorder · score 0.79
- autism · score 0.72
- Autism · score 0.58
- genetic disorder · score 0.50
- Moderate global developmental delay · score 0.49
- Intellectual disability · score 0.47
- complex neurodevelopmental disorder · score 0.46
- Neurodevelopmental disorder · score 0.45
- Seizure · score 0.44
- Autistic behavior · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16650-F1 | alphafold | PREDICTED | 55.04 | — |
Amino-acid sequence (682 residues)
MQLEHCLSPS IMLSKKFLNV SSSYPHSGGS ELVLHDHPII STTDNLERSS PLKKITRGMT NQSDTDNFPD SKDSPGDVQR SKLSPVLDGV SELRHSFDGS AADRYLLSQS SQPQSAATAP SAMFPYPGQH GPAHPAFSIG SPSRYMAHHP VITNGAYNSL LSNSSPQGYP TAGYPYPQQY GHSYQGAPFY QFSSTQPGLV PGKAQVYLCN RPLWLKFHRH QTEMIITKQG RRMFPFLSFN ISGLDPTAHY NIFVDVILAD PNHWRFQGGK WVPCGKADTN VQGNRVYMHP DSPNTGAHWM RQEISFGKLK LTNNKGASNN NGQMVVLQSL HKYQPRLHVV EVNEDGTEDT SQPGRVQTFT FPETQFIAVT AYQNTDITQL KIDHNPFAKG FRDNYDTIYT GCDMDRLTPS PNDSPRSQIV PGARYAMAGS FLQDQFVSNY AKARFHPGAG AGPGPGTDRS VPHTNGLLSP QQAEDPGAPS PQRWFVTPAN NRLDFAASAY DTATDFAGNA ATLLSYAAAG VKALPLQAAG CTGRPLGYYA DPSGWGARSP PQYCGTKSGS VLPCWPNSAA AAARMAGANP YLGEEAEGLA AERSPLPPGA AEDAKPKDLS DSSWIETPSS IKSIDSSDSG IYEQAKRRRI SPADTPVSES SSPLKSEVLA QRDCEKNCAK DISGYYGFYS HS
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