About NADP-dependent malic enzyme, mitochondrial
NADP-dependent malic enzyme, mitochondrial (ME3) is a protein
from Homo sapiens identified by UniProt accession
Q16798, 604 residues long.
MolForge cross-references it against 0 known binders and
32 disease associations.
Target properties
| Protein name | NADP-dependent malic enzyme, mitochondrial |
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| UniProt accession | Q16798 |
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| Gene | ME3 |
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| Organism | Homo sapiens |
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| Length | 604 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (32)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.49
- mean corpuscular volume · score 0.46
- lymphocyte count · score 0.46
- intraocular pressure measurement · score 0.43
- glaucoma · score 0.42
- red blood cell density measurement · score 0.41
- open-angle glaucoma · score 0.41
- erythrocyte count · score 0.39
- mean corpuscular hemoglobin · score 0.38
- mean corpuscular hemoglobin concentration · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16798-F1 | alphafold | PREDICTED | 91.69 | — |
Amino-acid sequence (604 residues)
MGAALGTGTR LAPWPGRACG ALPRWTPTAP AQGCHSKPGP ARPVPLKKRG YDVTRNPHLN KGMAFTLEER LQLGIHGLIP PCFLSQDVQL LRIMRYYERQ QSDLDKYIIL MTLQDRNEKL FYRVLTSDVE KFMPIVYTPT VGLACQHYGL TFRRPRGLFI TIHDKGHLAT MLNSWPEDNI KAVVVTDGER ILGLGDLGCY GMGIPVGKLA LYTACGGVNP QQCLPVLLDV GTNNEELLRD PLYIGLKHQR VHGKAYDDLL DEFMQAVTDK FGINCLIQFE DFANANAFRL LNKYRNKYCM FNDDIQGTAS VAVAGILAAL RITKNKLSNH VFVFQGAGEA AMGIAHLLVM ALEKEGVPKA EATRKIWMVD SKGLIVKGRS HLNHEKEMFA QDHPEVNSLE EVVRLVKPTA IIGVAAIAGA FTEQILRDMA SFHERPIIFA LSNPTSKAEC TAEKCYRVTE GRGIFASGSP FKSVTLEDGK TFIPGQGNNA YVFPGVALGV IAGGIRHIPD EIFLLTAEQI AQEVSEQHLS QGRLYPPLST IRDVSLRIAI KVLDYAYKHN LASYYPEPKD KEAFVRSLVY TPDYDSFTLD SYTWPKEAMN VQTV
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