About Leukotriene C4 synthase
Leukotriene C4 synthase (LTC4S) is a protein
from Homo sapiens identified by UniProt accession
Q16873, 150 residues long.
MolForge cross-references it against 0 known binders and
104 disease associations.
Target properties
| Protein name | Leukotriene C4 synthase |
|---|
| UniProt accession | Q16873 |
|---|
| Gene | LTC4S |
|---|
| Organism | Homo sapiens |
|---|
| Length | 150 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (104)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.14
- hypotonia-failure to thrive-microcephaly syndrome · score 0.12
- asthma, nasal polyps, and aspirin intolerance · score 0.12
- monocyte count · score 0.10
- lung adenocarcinoma · score 0.07
- resting heart rate · score 0.07
- lymphocyte:monocyte ratio · score 0.07
- platelet count · score 0.06
- granulocyte percentage of myeloid white cells · score 0.06
- autoimmune disease · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16873-F1 | alphafold | PREDICTED | 97.16 | — |
Amino-acid sequence (150 residues)
MKDEVALLAA VTLLGVLLQA YFSLQVISAR RAFRVSPPLT TGPPEFERVY RAQVNCSEYF PLFLATLWVA GIFFHEGAAA LCGLVYLFAR LRYFQGYARS AQLRLAPLYA SARALWLLVA LAALGLLAHF LPAALRAALL GRLRTLLPWA
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