About Thioredoxin reductase 1, cytoplasmic
Thioredoxin reductase 1, cytoplasmic (TXNRD1) is a protein
from Homo sapiens identified by UniProt accession
Q16881, 649 residues long.
MolForge cross-references it against 0 known binders and
260 disease associations.
Target properties
| Protein name | Thioredoxin reductase 1, cytoplasmic |
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| UniProt accession | Q16881 |
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| Gene | TXNRD1 |
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| Organism | Homo sapiens |
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| Length | 649 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (260)
Diseases linked to this target (Open Targets).
- acute promyelocytic leukemia · score 0.57
- neoplasm · score 0.42
- diphtheria · score 0.37
- rheumatic disease · score 0.37
- leukemia · score 0.30
- acute myeloid leukemia · score 0.30
- myelodysplastic syndrome · score 0.30
- brain neoplasm · score 0.28
- metastasis · score 0.28
- metastatic malignant neoplasm · score 0.26
Amino-acid sequence (649 residues)
MGCAEGKAVA AAAPTELQTK GKNGDGRRRS AKDHHPGKTL PENPAGFTST ATADSRALLQ AYIDGHSVVI FSRSTCTRCT EVKKLFKSLC VPYFVLELDQ TEDGRALEGT LSELAAETDL PVVFVKQRKI GGHGPTLKAY QEGRLQKLLK MNGPEDLPKS YDYDLIIIGG GSGGLAAAKE AAQYGKKVMV LDFVTPTPLG TRWGLGGTCV NVGCIPKKLM HQAALLGQAL QDSRNYGWKV EETVKHDWDR MIEAVQNHIG SLNWGYRVAL REKKVVYENA YGQFIGPHRI KATNNKGKEK IYSAERFLIA TGERPRYLGI PGDKEYCISS DDLFSLPYCP GKTLVVGASY VALECAGFLA GIGLDVTVMV RSILLRGFDQ DMANKIGEHM EEHGIKFIRQ FVPIKVEQIE AGTPGRLRVV AQSTNSEEII EGEYNTVMLA IGRDACTRKI GLETVGVKIN EKTGKIPVTD EEQTNVPYIY AIGDILEDKV ELTPVAIQAG RLLAQRLYAG STVKCDYENV PTTVFTPLEY GACGLSEEKA VEKFGEENIE VYHSYFWPLE WTIPSRDNNK CYAKIICNTK DNERVVGFHV LGPNAGEVTQ GFAAALKCGL TKKQLDSTIG IHPVCAEVFT TLSVTKRSGA SILQAGCUG
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