Dual oxidase maturation factor 1 (DUOXA1)

About Dual oxidase maturation factor 1

Dual oxidase maturation factor 1 (DUOXA1) is a protein from Homo sapiens identified by UniProt accession Q1HG43, 343 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.

Target properties

Protein name	Dual oxidase maturation factor 1
UniProt accession	Q1HG43
Gene	DUOXA1
Organism	Homo sapiens
Length	343 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (57)

Diseases linked to this target (Open Targets).

drug use measurement · score 0.16
genetic disorder · score 0.15
cortical thickness · score 0.09
brain measurement · score 0.08
creatinine measurement · score 0.06
serum iron measurement · score 0.04
Crohn's disease · score 0.03
ferritin measurement · score 0.02
prostate carcinoma · score 0.02
sessile serrated polyp · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q1HG43-F1	alphafold	PREDICTED	82.47	—

Amino-acid sequence (343 residues)

MATLGHTFPF YAGPKPTFPM DTTLASIIMI FLTALATFIV ILPGIRGKTR LFWLLRVVTS LFIGAAILAV NFSSEWSVGQ VSTNTSYKAF SSEWISADIG LQVGLGGVNI TLTGTPVQQL NETINYNEEF TWRLGENYAE EYAKALEKGL PDPVLYLAEK FTPRSPCGLY RQYRLAGHYT SAMLWVAFLC WLLANVMLSM PVLVYGGYML LATGIFQLLA LLFFSMATSL TSPCPLHLGA SVLHTHHGPA FWITLTTGLL CVLLGLAMAV AHRMQPHRLK AFFNQSVDED PMLEWSPEEG GLLSPRYRSM ADSPKSQDIP LSEASSTKAY CKEAHPKDPD CAL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards