About Leucine-rich repeat-containing protein 36
Leucine-rich repeat-containing protein 36 (LRRC36) is a protein
from Homo sapiens identified by UniProt accession
Q1X8D7, 754 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | Leucine-rich repeat-containing protein 36 |
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| UniProt accession | Q1X8D7 |
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| Gene | LRRC36 |
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| Organism | Homo sapiens |
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| Length | 754 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (37)
Diseases linked to this target (Open Targets).
- erythrocyte count · score 0.27
- BMI-adjusted waist-hip ratio · score 0.26
- neurodegenerative disease · score 0.23
- BMI-adjusted waist circumference · score 0.21
- mean corpuscular volume · score 0.20
- smoking behavior · score 0.18
- blood protein measurement · score 0.17
- cystatin C measurement · score 0.17
- waist-hip ratio · score 0.17
- mean corpuscular hemoglobin concentration · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q1X8D7-F1 | alphafold | PREDICTED | 54.33 | — |
Amino-acid sequence (754 residues)
MAEQWELDEE GIRRLGALTL EQPELVESLS LQGSYAGKIH SIGDAFRNFK NLRSLDLSRN LITSLKGIQY LCSLQDLNLY YNNIPSLVEV SRLQPLPFLK ELDLRLNPVV RKDTDYRLFA VYTLQTLEKL DDRTVREGER KAAKLHFSQL GNSENFLLEV EKSSREKTMK NCVTGESSAS KVSANVDSRI EMDSNKGLFI PFPNREIKDS LSTSATQGNG TRDQKLDTFP LGTQTQEVAR REMPSDNHQE DEFRHYSPRQ STVRSPEKMT REGYQVSFLD NKSSGSSPEK ELIPKPDTFH LTHDASLSKC LDVGDSSQIH PYQLPSDVGL ENYDSCYSQT LSLHGSLGKR PQRSKNYQEY SIKPSNDIKT TASHSCGDLL TSLSNPDSST GRLLKLSSDL YATTHFNSDP AVLVNVEQQL STSLDDLTPA HGSVPNNAVL GNRTTPLRTL LLSPGTSEHR KIFTKRSLSP SKRGFKWKDN ILANLNLKHG FQDATGSEPL SSDLGSLHGL AGNHSPPISA RTPHVATVLR QLLELVDKHW NGSGSLLLNK KFLGPARDLL LSLVVPAPSQ PRCCSHPEDT MKAFCRRELE LKEAAQLVPN DMESLKQKLV RVLEENLILS EKIQQLEEGA AISIVSGQQS HTYDDLLHKN QQLTMQVACL NQELAQLKKL EKTVAILHES QRSLVVTNEY LLQQLNKEPK GYSGKALLPP EKGHHLGRSS PFGKSTLSSS SPVAHETGQY LIQSVLDAAP EPGL
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