Leucine-rich repeat-containing protein 26 (LRRC26)

About Leucine-rich repeat-containing protein 26

Leucine-rich repeat-containing protein 26 (LRRC26) is a protein from Homo sapiens identified by UniProt accession Q2I0M4, 334 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.

Target properties

Protein name	Leucine-rich repeat-containing protein 26
UniProt accession	Q2I0M4
Gene	LRRC26
Organism	Homo sapiens
Length	334 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (18)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.28
triple-negative breast cancer · score 0.02
colitis · score 0.02
ulcerative colitis · score 0.01
neoplasm · score 0.01
gonorrhea · score 0.01
cancer · score 0.01
calf circumference measurement · score 0.01
Crohn's disease · score 0.01
Leishmaniasis · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q2I0M4-F1	alphafold	PREDICTED	82.50	—

Amino-acid sequence (334 residues)

MRGPSWSRPR PLLLLLLLLS PWPVWAQVSA TASPSGSLGA PDCPEVCTCV PGGLASCSAL SLPAVPPGLS LRLRALLLDH NRVRALPPGA FAGAGALQRL DLRENGLHSV HVRAFWGLGA LQLLDLSANQ LEALAPGTFA PLRALRNLSL AGNRLARLEP AALGALPLLR SLSLQDNELA ALAPGLLGRL PALDALHLRG NPWGCGCALR PLCAWLRRHP LPASEAETVL CVWPGRLTLS PLTAFSDAAF SHCAQPLALR DLAVVYTLGP ASFLVSLASC LALGSGLTAC RARRRRLRTA ALRPPRPPDP NPDPDPHGCA SPADPGSPAA AAQA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards