About Intestine-specific homeobox
Intestine-specific homeobox (ISX) is a protein
from Homo sapiens identified by UniProt accession
Q2M1V0, 245 residues long.
MolForge cross-references it against 0 known binders and
88 disease associations.
Target properties
| Protein name | Intestine-specific homeobox |
|---|
| UniProt accession | Q2M1V0 |
|---|
| Gene | ISX |
|---|
| Organism | Homo sapiens |
|---|
| Length | 245 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (88)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.26
- esophageal adenocarcinoma · score 0.19
- breast carcinoma · score 0.19
- gastric carcinoma · score 0.18
- myelodysplastic syndrome · score 0.18
- acute myeloid leukemia · score 0.18
- chronic lymphocytic leukemia · score 0.18
- clear cell renal carcinoma · score 0.18
- colorectal adenocarcinoma · score 0.18
- head and neck squamous cell carcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2M1V0-F1 | alphafold | PREDICTED | 65.41 | — |
Amino-acid sequence (245 residues)
MCAEVGPALC RGMERNSLGC CEAPKKLSLS FSIEAILKRP ARRSDMDRPE GPGEEGPGEA AASGSGLEKP PKDQPQEGRK SKRRVRTTFT TEQLHELEKI FHFTHYPDVH IRSQLAARIN LPEARVQIWF QNQRAKWRKQ EKIGNLGAPQ QLSEASVALP TNLDVAGPTW TSTALRRLAP PTSCCPSAQD QLASAWFPAW ITLLPAHPWE TQPVPGLPIH QTCIPVLCIL PPPHPKWGSI CATST
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