About Sprouty-related, EVH1 domain-containing protein 3
Sprouty-related, EVH1 domain-containing protein 3 (SPRED3) is a protein
from Homo sapiens identified by UniProt accession
Q2MJR0, 410 residues long.
MolForge cross-references it against 0 known binders and
23 disease associations.
Target properties
| Protein name | Sprouty-related, EVH1 domain-containing protein 3 |
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| UniProt accession | Q2MJR0 |
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| Gene | SPRED3 |
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| Organism | Homo sapiens |
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| Length | 410 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (23)
Diseases linked to this target (Open Targets).
- cancer · score 0.37
- neurofibromatosis-Noonan syndrome · score 0.37
- breast adenocarcinoma · score 0.29
- cutaneous melanoma · score 0.12
- head and neck squamous cell carcinoma · score 0.12
- major depressive disorder · score 0.07
- obsessive-compulsive disorder · score 0.06
- neoplasm · score 0.04
- thyroid carcinoma · score 0.04
- prostate carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2MJR0-F1 | alphafold | PREDICTED | 65.15 | — |
Amino-acid sequence (410 residues)
MVRVRAVVMA RDDSSGGWLP VGGGGLSQVS VCRVRGARPE GGARQGHYVI HGERLRDQKT TLECTLKPGL VYNKVNPIFH HWSLGDCKFG LTFQSPAEAD EFQKSLLAAL AALGRGSLTP SSSSSSSSPS QDTAETPCPL TSHVDSDSSS SHSRQETPPS AAAAPIITME SASGFGPTTP PQRRRSSAQS YPPLLPFTGI PEPSEPLAGA GGLGWGGRGY EDYRRSGPPA PLALSTCVVR FAKTGALRGA ALGPPAALPA PLTEAAPPAP PARPPPGPGP SSAPAKASPE AEEAARCVHC RALFRRRADG RGGRCAEAPD PGRLLVRRLS CLWCAESLLY HCLSDAEGDF SDPCACEPGH PRPAARWAAL AALSLAVPCL CCYAPLRACH WVAARCGCAG CGGRHEEAAR
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