About Complement component receptor 1-like protein
Complement component receptor 1-like protein (CR1L) is a protein
from Homo sapiens identified by UniProt accession
Q2VPA4, 569 residues long.
MolForge cross-references it against 0 known binders and
91 disease associations.
Target properties
| Protein name | Complement component receptor 1-like protein |
|---|
| UniProt accession | Q2VPA4 |
|---|
| Gene | CR1L |
|---|
| Organism | Homo sapiens |
|---|
| Length | 569 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (91)
Diseases linked to this target (Open Targets).
- blood sedimentation · score 0.29
- hematocrit · score 0.22
- Alzheimer disease · score 0.16
- family history of Alzheimer’s disease · score 0.15
- Red cell distribution width · score 0.12
- genetic disorder · score 0.12
- X-21444 measurement · score 0.11
- adolescent idiopathic scoliosis · score 0.11
- late-onset Alzheimers disease · score 0.11
- vital capacity · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2VPA4-F1 | alphafold | PREDICTED | 83.22 | — |
Amino-acid sequence (569 residues)
MAPPVRLERP FPSRRFPGLL LAALVLLLSS FSDQCNVPEW LPFARPTNLT DDFEFPIGTY LNYECRPGYS GRPFSIICLK NSVWTSAKDK CKRKSCRNPP DPVNGMAHVI KDIQFRSQIK YSCPKGYRLI GSSSATCIIS GNTVIWDNKT PVCDRIICGL PPTIANGDFT SISREYFHYG SVVTYHCNLG SRGKKVFELV GEPSIYCTSK DDQVGIWSGP APQCIIPNKC TPPNVENGIL VSDNRSLFSL NEVVEFRCQP GFGMKGPSHV KCQALNKWEP ELPSCSRVCQ PPPDVLHAER TQRDKDNFSP GQEVFYSCEP GYDLRGSTYL HCTPQGDWSP AAPRCEVKSC DDFLGQLPNG HVLFPLNLQL GAKVDFVCDE GFQLKGSSAS YCVLAGMESL WNSSVPVCER KSCETPPVPV NGMVHVITDI HVGSRINYSC TTGHRLIGHS SAECILSGNT AHWSMKPPIC QQIFCPNPPA ILNGRHTGTP LGDIPYGKEV SYTCDPHPDR GMTFNLIGES TIRRTSEPHG NGVWSSPAPR CELPVGAGSH DALIVGKFYE VFAEEFCHL
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