Leucine-rich repeat-containing protein 75B (LRRC75B)

About Leucine-rich repeat-containing protein 75B

Leucine-rich repeat-containing protein 75B (LRRC75B) is a protein from Homo sapiens identified by UniProt accession Q2VPJ9, 315 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.

Target properties

Protein name	Leucine-rich repeat-containing protein 75B
UniProt accession	Q2VPJ9
Gene	LRRC75B
Organism	Homo sapiens
Length	315 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (15)

Diseases linked to this target (Open Targets).

serum gamma-glutamyl transferase measurement · score 0.59
liver enzyme measurement · score 0.16
urinary metabolite measurement · score 0.09
calcium measurement · score 0.07
alcoholic liver disease · score 0.07
serum metabolite measurement · score 0.06
protein measurement · score 0.06
liver fibrosis measurement · score 0.04
non-alcoholic fatty liver disease · score 0.04
blood metabolite measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q2VPJ9-F1	alphafold	PREDICTED	71.62	—

Amino-acid sequence (315 residues)

MGARLGRRAG PEAGSEAGAA AGCGPAPYER RVRWLREIQS TLRERRPERA RQLLRLLRQD LGLERTLLPD ILYRDVAFLN PVDPISHDLL VNLARDLQCP KKDYELWKSS DKICRQLIYH LTPHSKQQQG SSLRQRKTQS CLKSSLQKTL LAGETVDLSG IPLSTQDVQH ITRYLSSHGA VLAVLDLSFT GLSDELLHLL LPSLWALPRL TQLLLNGNRL TRATARKLTD AIKDTTKFPA LAWVDLGNNV DVASLPQPLL VGLRRRLSQR TSLPTIYEGL DLEPEGSAAG ATTPASTWDS TAAGLGPEPQ ACCAR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards