About Cation channel sperm-associated auxiliary subunit theta
Cation channel sperm-associated auxiliary subunit theta (CATSPERQ) is a protein
from Homo sapiens identified by UniProt accession
Q2WGJ8, 235 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | Cation channel sperm-associated auxiliary subunit theta |
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| UniProt accession | Q2WGJ8 |
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| Gene | CATSPERQ |
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| Organism | Homo sapiens |
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| Length | 235 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (84)
Diseases linked to this target (Open Targets).
- epidermolysis bullosa simplex with nail dystrophy · score 0.11
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- spermatogenic failure 55 · score 0.06
- spermatogenic failure 3 · score 0.06
- partial chromosome Y deletion · score 0.06
- spermatogenic failure 7 · score 0.06
- spermatogenic failure 49 · score 0.06
- spermatogenic failure 43 · score 0.06
- spermatogenic failure 45 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2WGJ8-F1 | alphafold | PREDICTED | 78.53 | — |
Amino-acid sequence (235 residues)
MPKGRAGSLP TTSIGWRFQL WFLGLTCPER HLARRLKNNS FYPFVQQEPN VFVLEYYLDT LWKGMLLFII SVVLVSFSSL REVQKQETWV FLVYGVGVGL WLVISSLPRR RLVLNHTRGV YHFSIQGRTV CQGPLHLVYV RLALSSDAHG RCFFHLVLGG HRLEPLVLVQ LSEHYEQMEY LGRYIARKLN INYFDYLATS YRHVVRHWPP PGAGTVMGKS PMGHKPSSSQ SSLEV
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